Publications & Patents

Publications

116. Discovery and Characterization of Active CBP/EP300 Degraders Targeting the HAT Domain

I. Cheng-Sánchez, K. A. Gosselé, L. Palaferri, M. S. Kirillova, C. Nevado*

doi.org/10.1021/acsmedchemlett.3c00490

 

 

115. Dual Nickel/Photoredox-Catalyzed Asymmetric Carbamoylation of Benzylic C(sp3)-H Bonds
S. Cuesta-Galisteo, J. Schoergenhumer, C. Hervieu, C. Nevado*

Angew. Chem. Int. Ed. (2024), e202313717

Open Access

 

 

114. Chiral arylsulfinylamides as reagents for visible light-mediated asymmetric alkene aminoarylations

C.Hervieu, M. S. Kirillova, Y. Hu, S. Cuesta-Galisteo, E. Merino*, C. Nevado*

doi.org/10.1038/s41557-023-01414-8

Open Access

 

 

113. Dual Nickel/Photoredox-Catalyzed Asymmetric Carbosulfonylation of Alkenes

X. Du, I. Cheng-Sánchez, C. Nevado*

J. Am. Chem. Soc. (2023), 145, 12532−12540

Open Access

 

 

112. Nickel-Catalyzed Enantioselective Electrochemical Reductive Cross-Coupling of Aryl Aziridines with Alkenyl Bromides

X. Hu, I. Cheng-Sánchez, S. Cuesta-Galisteo, C. Nevado*

J. Am. Chem. Soc. (2023), 145, 6270–6279

Open Access

 

 

111. Synthesis of Cyclometalated Gold(III) Complexes via Catalytic Rhodium to Gold(III) Transmetalation

J. Martín, E. Gómez-Bengoa, A. Genoux, C. Nevado*

Angew. Chem. Int. Ed. (2022), e202116755

 

 

110. Chelation-assisted C–C bond activation of biphenylene by gold(i) halides

H. Beucher, J. Schörgenhumer, E. Merino, C. Nevado*

Chem. Sci. (2021),12, 15084-15089

 

 

109. Asymmetric, visible light-mediated radical sulfinyl-Smiles rearrangement to access all-carbon quaternary stereocentres

C. Hervieu, M. S. Kirillova, T. Suárez, M. Müller, E. Merino*, C. Nevado*

Nat. Chem. (2021), 13, 327-334

 

 

 

108. Diaryl Ether Formation Merging Photoredox and Nickel Catalysis

L. Liu, C. Nevado*

Organometallics. (2021), 40, 2188–2193

 

 

 

107. Synthesis and Characterization of Bidentate (P^N)Gold(III) Fluoride Complexes: Reactivity Platforms for Reductive Elimination Studies

A. Genoux, M. Biedrzycki, E. Merino, E. Rivera, A. Linden, C. Nevado*

Angew. Chem. Int. Ed. (2021), 60, 4164-4168

 

 

 

106. Nickel‐Catalyzed Asymmetric Synthesis of α‐Arylbenzamides

S. Cuesta-Galisteo, J. Schörgenhumer, X. Wei, E. Merino, C. Nevado*

Angew. Chem. Int. Ed. (2021), 60, 1605–1609

 

 

 

105. Phosphorescent k3‐(N^C^C)‐Gold(III) Complexes: Synthesis, Photophysics, Computational Studies and Application to Solution‐Processable OLEDs

H. Beucher, S. Kumar, R. Kumar, E. Merino, W.-H. Hu, G. Stemmler, S. Cuesta-Galisteo, J. A. Gonzalez, L. Bezinge, J. Jagielski, C.-J. Shih*, C. Nevado*

Chem. Eur. J. (2020), 26, 17604–17612

 

 

104. [C^N]‐Alkenyl Gold(III) Complexes by Proximal Ring‐Opening of (2‐Pyridyl)alkylidenecyclopropanes: Mechanistic Insights

J. A. González, F. Verdugo, J. L. Mascareñas, F. López, C. Nevado*

Angew. Chem. Int. Ed. (2020), 59, 20049–20054

 

 

 

103. Mechanistic Insights into C(sp2)−C(sp)N Reductive Elimination from Gold(III) Cyanide Complexes

A. Genoux, J. A. González, E. Merino, C. Nevado*

Angew. Chem. Int. Ed. (2020), 59, 2–8

 

 

 

102. Hitting a Moving Target: Simulation and Crystallography Study of ATAD2 Bromodomain Blockers

A. Dolbois, L. Batiste, L. Wiedmer, J. Dong, M. Brütsch, D. Huang, N. M. Deerain, D. Spiliotopoulos, I. Cheng-Sánchez, E. Laul, C. Nevado*, P. Śledź*, A. Caflisch*

ACS Med. Chem. Lett. (2020), 11, 1573–1580

 

 

 

101. Asymmetric Ni-Catalyzed Radical Relayed Reductive Coupling

X. Wei, W. Shu, A. García-Domínguez, E. Merino, C. Nevado*

J. Am. Chem. Soc. (2020), 142, 13515–13522

(highlighted by Organic Chemistry Portal)

 

 

 

100. Understanding the Mechanism of Action of Pyrrolo[3,2-b]quinoxaline-derivatives as Kinase Inhibitors

A. Unzue, C. Jessen-Trefzer, D. Spiliotopoulos, E. Gaudio, C. Tarantelli, J. Dong, H. Zhao, J. Pachmayr, S. Zahler, E. Bernasconi, G. Sartori, L. Cascione, F. Bertoni*, P. Śledź, A. Caflisch*, C. Nevado*

RSC Med. Chem. (2020), 11, 665-675

 

 

 

99. Highly Efficient Green Solution Processable OLEDs Based on a Phosphorescent Κ3-(N^C^C)Gold(III)-Alkynyl Complex

H. Beucher, S. Kumar, E. Merino, W.-H. Hu, G. Stemmler, S. Cuesta-Galisteo, J. A. González, J. Jagielski, C.-J. Shih*, C. Nevado*

Chem. Mater. (2020), 32, 1605–1611

 

 

 

98. Ni-Catalyzed Reductive Dicarbofunctionalization of Nonactivated Alkenes: Scope and Mechanistic Insights

W. Shu, A. García-Domínguez, M. T. Quirós, R. Mondal, D. J. Cárdenas, C. Nevado*

J. Am. Chem. Soc. (2019), 141, 13812-13821

 

 

 

97. Oxidant speciation and anionic ligand effects in the gold-catalyzed oxidative coupling of arenes and alkynes

Manuel Hofer, Teresa de Haro, Enrique Gómez-Bengoa, Alexandre Genoux, Cristina Nevado*

Chem. Sci. (2019),10, 8411-8420

 

 

 

96. Dual Photoredox/Nickel‐Catalyzed Three‐Component Carbofunctionalization of Alkenes

A. García-Domínguez, R. Mondal, C. Nevado*

Angew. Chem. Int. Ed. (2019), 58, 12286-12290

 

 

 

95. k3-(N^C^C)Gold(III) Carboxylates: Evidence for Decarbonylation Processes

H. Beucher, E. Merino, A. Genoux, T. Fox, C. Nevado*

Angew. Chem. Int. Ed. (2019), 58, 9064-9067

 

This paper was also highlighted as one of the most interesting recent publications of Swiss origin in the August 2019 issue of CHIMIA International Journal for Chemistry Column: Swiss Science Concentrates! [Chimia (2019) 73, 634]

 

 

94. Binding Motifs in the CBP Bromodomain: An Analysis of 20 Crystal Structures of Complexes with Small Molecules

J. Zhu, J. Dong, L. Batiste, A. Unzue, A. Dolbois, V. Pascanu, P. Sledz, C. Nevado*, A. Caflisch*

ACS Med. Chem. Lett. (2018), 9, 929-934
 

 

 

93. Visible Light Mediated, Redox Neutral Remote 1,6-Difunctionalizations of Alkenes

W. Shu, E. Merino, C. Nevado*

ACS Catalysis (2018), 8, 6401-6406

 

 

 

92. Transforming Olefins into Dinucleophiles

A. García-Domínguez, C. Nevado*

Chimia (2018), 72, 212-215

 

 

91. Structural Analysis of Small Molecule Binding to the BAZ2A and BAZ2B Bromodomains

A. D. Vedove, D. Spiliotopoulos, V. G. D´Agostino, J. R. Marchand, A. Unzue, C. Nevado, G. Lolli*, A. Caflisch*

ChemMedChem (2018), 13,1479 –1487 

 

 

90. Iriomoteolides: Novel Chemical Tools to Study Actin Dynamics

A. Unzue, R. CribiÙ, M. M. Hoffman, T. Knehans, K. Lafleur, A. Caflisch*, C. Nevado*

Chem. Sci. (2018), 9, 3793-3802

 

 

 

89. Chemical Space Expansion of Bromodomain Ligands Guided by in Silico Virtual Couplings (AutoCouple)

L. Batiste, A. Unzue, A. Dolbois, F. Hassler, X. Wang, N. Deerain, J. Zhu, D. Spiliotopoulos, C. Nevado*, A. Caflisch*

ACS Cent. Sci., (2018), 4, 180–188

 

 

 

88. Gold-catalyzed oxidative aminoesterification of unactivated alkenes

P. Feige, T. de Haro, G. Rusconi, E. Merino, C. Nevado*

Monatsh. Chem. (2018), 149, 749-754

 

 

 

87. The First Gold(III) Formate: Evidence for β-Hydride Elimination

R. Kumar, J.-P, Krieger, E. Gómez-Bengoa, T. Fox, A. Linden, C. Nevado*

Angew. Chem. Int. Ed. (2017), 56, 12862–12865

 

 

 

86. γ-Functionalizations of Amines through Visible-Light-Mediated, Redox-Neutral C−C Bond Cleavage

W. Shu, A. Genoux, Z. Li, C. Nevado*

Angew. Chem. Int. Ed. (2017), 56, 10521–10524

 

 

 

85. Nickel-Catalyzed Intermolecular Carbosulfonylation of Alkynes via Sulfonyl Radicals

A. García-Domínguez, S. Müller, C. Nevado*

Angew. Chem. Int. Ed. (2017), 56, 9949–9952

 

 

 

84. Nickel-Catalyzed Reductive Dicarbofunctionalization of Alkenes

A. García-Domínguez, Z. Li, C. Nevado*

J. Am. Chem. Soc. (2017), 139, 6835-6838

 

 

 

83. Stereoselective Carboperfluoroalkylation of Internal Alkynes: Mechanistic Insights

Z. Li, E. Merino, C. Nevado*

Top. Catal. (2017), 60, 545-553

(Special Issue in honour of Prof. Donna Blackmond)

 

 

 

82. Visible-Light-Mediated Remote Aliphatic C−H Functionalizations through a 1,5-Hydrogen Transfer Cascade

W. Shu, C. Nevado*

Angew. Chem. Int. Ed. (2017), 56, 1881-1884

 

 

 

81. Expeditious diastereoselective synthesis of elaborated ketones via remote Csp3–H functionalization

W. Shu, A. Lorente, E. Gómez-Bengoa, C. Nevado*

Nature Commun. (2017), 8, 13832

 

 

 

80. A Gold- and Brønsted acid Catalytic Interplay Towards the Synthesis of Highly Substituted Tetrahydrocarbazoles

D. Garayalde, G. Rusconi, C. Nevado*

Helv. Chim. Acta (2017), 100, e1600333

 

 

 

79. Gold-Catalyzed Direct Oxidative Arylation with Boron Coupling Partners

M. Hofer, A. Genoux, R. Kumar, C. Nevado*

Angew. Chem. Int. Ed. (2017), 56, 1021-1025

 

 

 

78. Cyclometalated Au(III) complexes: Synthesis, Reactivity and Physicochemical Properties

R. Kumar, C. Nevado*

Angew. Chem. Int. Ed. (2017), 56, 1994-2015

 

 

 

77. Evidence for Direct Transmetalation of AuIII-F with Boronic Acids

R. Kumar, A. Linden, C. Nevado*

J. Am. Chem. Soc. (2016), 138, 13790-13793

 

 

 

76. In Vivo Performance and Properties of Tamoxifen Metabolites for CreERT2 Control

A. Felker, S. Nieuwenhuize, A. Dolbois, K. Blazkova, C. Hess, L. W. L. Low, S. Burger, N. Samson, T. J. Carney, P. Bartunek, C. Nevado, C. Mosimann*

PLOS ONE (2016), 11, e0152989/1-e0152989/17

 

 

75. Nickel-Catalyzed Stereoselective Dicarbofunctionalization of Alkynes

Z. Li, A. García-Domínguez, C. Nevado*

Angew. Chem. Int. Ed. (2016), 55, 6938-6941

 

 

 

74. The “gatekeeper” residue influences the binding mode of acetyl indoles to bromodomains

A. Unzue, H. Zhao, G. Lolli, J. Dong, J. Zhu, M. Zechner, A. Dolbois, A. Caflisch*, C. Nevado*

J. Med. Chem. (2016), 59, 3087-3097

 

 

 

73. Palladium-catalyzed incorporation of atmospheric CO2: efficient synthesis of functionalized oxazolidinones

P. García-Domínguez, L. Fehr, G. Rusconi, C. Nevado*

Chem. Sci. (2016), 7, 3914-3918

 

 

 

72. Au–Pd Bimetallic Catalysis: The Importance of Anionic Ligands in Catalyst Speciation

P. García-Domínguez, C. Nevado*

J. Am. Chem. Soc. (2016), 138, 3266-3269

 

 

 

71. Three stories on Eph kinase inhibitors: from in silico discovery to in vivo validation

A. Unzue, K. Lafleur, H. Zhao, T. Zhou, J. Dong, P. Kolb, J. Liebl, S. Zahler, A. Caflisch*, C. Nevado*

Eur. J. Med. Chem. (2016), 112, 347-366

 

 

 

70. Gold-Mediated Reactions

E. Merino, A. Salvador, C. Nevado

Science of Synthesis, Applications of Domino Transformations in Organic Synthesis 1, 2015/4a, 535-576

 

 

 

69. Luminescent (N^C^C)-Gold(III) Complexes: Stabilized Gold(III) Fluorides

R. Kumar, A. Linden, C. Nevado*

Angew. Chem., Int. Ed. (2015), 54, 14287-14290

 

 

 

68. Pd-Catalyzed Stereoselective Carboperfluoroalkylation of Alkynes

Z. Li, A. García-Domínguez, C. Nevado*

J. Am. Chem. Soc. (2015), 137, 11610-11613

 

 

 

67. Discovery of CREBBP Bromodomain Inhibitors by High-Throughput Docking and Hit Optimization Guided by Molecular Dynamics

M. Xu, A. Unzue, J. Dong, D. Spiliotopoulos, C. Nevado*, A. Caflisch*

J. Med. Chem. (2016), 59, 1340–1349

 

 

 

66.  Fragment-based Design of Selective Nanomolar Ligands of the CREBBP Bromodomain

A. Unzue, M. Xu, J. Dong, L. Wiedmer, D. Spiliotopoulos, A. Caflisch*, C. Nevado*

J. Med. Chem. (2016), 59, 1350-1356

 

 

 

65. Stereoselective Synthesis of Highly Functionalized Indanes and Dibenzocycloheptadienes through Complex Radical Cascade Reactions

W. Kong, N. Fuentes, A. García-Domínguez, E. Merino, C. Nevado*

Angew. Chem. Int. Ed. (2015), 54, 2517-2521

 

 

 

64. Cyclization Cascades via N-Amidyl Radicals toward Highly Functionalized Heterocyclic Scaffolds

N. Fuentes, W. Kong, L. Fernández-Sánchez, E. Merino, C. Nevado*

J. Am. Chem. Soc. (2015), 137, 964-973

 

 

 

63. Hydroarylation Reactions

T. de Haro, C. Nevado

Comprehensive Organic Synthesis (2nd Edition) (2014), 5, 1621-1659

 

 

62. Gold-catalyzed migrations and ring expansions

E. Merino, L. Fernández-Sánchez, C. Nevado

Patai's Chemistry of Functional Groups (Organogold Compounds), (2014), Pt. 1, 235-305

 

 

61. Pyrrolo[3,2-b]quinoxaline Derivatives as Types I1/2 and II Eph Tyrosine Kinase Inhibitors: Structure-Based Design, Synthesis, and in Vivo Validation

A. Unzue, J. Dong, K. Lafleur, H. Zhao, E. Frugier, A. Caflisch*, C. Nevado*

J. Med. Chem. (2014), 57, 6834–6844

 

 

 

60. Divergent Reaction Mechanisms in the Aminofluorination of Alkenes

W. Kong, E. Merino, C. Nevado*

Chimia (2014), 48, 430-435

 

 

59. Addition of CF3 across unsaturated moieties: a powerful functionalization tool

E. Merino*, C. Nevado*

Chem. Soc. Rev. (2014), 43, 6598-6608

 

Graphical abstract: Addition of CF3 across unsaturated moieties: a powerful functionalization tool

 

 

58. Arylphosphonylation and Arylazidation of Activated Alkenes

W. Kong, E. Merino, C. Nevado*

Angew. Chem. Int. Ed. (2014), 53, 5078-5082 (Hot Paper)

 

 

57. A Neutral Gold(III)-Boron Transmetalation

M. Hofer, E. Gómez-Bengoa, C. Nevado*

Organometallics (2014), 33, 1328-1332 (Cover Paper)

 

 

 

56. Metal-Free Aryltrifluoromethylation of Activated Alkenes

W. Kong, M. Casimiro, N. Fuentes, E. Merino, C. Nevado*

Angew. Chem. Int. Ed. (2013), 52, 13086-13090

 

 

 

55. On Gold Catalysis and Beyond...

E. Merino, C. Nevado*

Chimia (2013), 67, 663-668

 

 

54. Copper- Catalyzed One-Pot Trifluoromethylation/Aryl Migration/Desulfonylation and C(sp2)-N Bond Formation of Conjugated Tosyl Amides

W. Kong, M. Casimiro, E. Merino, C. Nevado*

J. Am. Chem. Soc. (2013), 135, 14480-14483

 

 

 

53. Cross-Coupling of Arene-Gold(III) Complexes

M. Hofer, C. Nevado*

Tetrahedron (2013), 69, 5751-5757

 

http://origin-ars.els-cdn.com/content/image/1-s2.0-S004040201300567X-fx1.jpg

 

 

52. Regio and Enantioselective Aminofluorination of Alkenes

W. Kong, P. Feige, T. de Haro, C. Nevado*

Angew. Chem. Int. Ed. (2013), 52, 2469-2473

(highlighted by Organic Chemistry Portal)

 

 

 

51. Optimization of Inhibitors of the Tyrosine Kinase EphB4. 2. Cellular Potency Improvement and Binding Mode Validation by X-ray Crystallography

K. Lafleur, J. Dong, D. Huang, A. Caflisch, C. Nevado*

J. Med. Chem. (2013), 56(1), 84-96

 

 

 

50. Gold-Catalyzed Reactions of Alkenes

T. de Haro, D. Garayalde, C. Nevado*

Science of Synthesis, Knowledge Updates, 2012/3, 171-225

 

 

 

49.  Synthetic Potential Behind Gold-Catalyzed Redox Processes

C. Nevado*, T. de Haro

New Strategies in Chemical Synthesis and Catalysis (2012), 247-272

 

New Strategies in Chemical Synthesis and Catalysis (3527330909) cover image

 

 

 

 

 

 

 

 

 

48. Discovery of a Novel Chemotype of Tyrosine Kinase Inhibitors by Fragment-Based Docking and Molecular Dynamics

H. Zhao, J. Dong, K. Lafleur, C. Nevado*, A. Caflisch*

J. Med. Chem. Lett. 2012, 3, 834-838

 

 

 

47. Dual Roles in Gold Catalysis

C. Nevado*

Abstracts of Papers, 244th ACS National Meeting & Exposition, Philadelphia, PA, United States, August 19-23, 2012 (2012), ORGN-401

 

 

46. Catalytic Applications of Gold Carbenes: Gold-Stabilized Carbocations

C. Nevado*

Abstracts of Papers, 244th ACS National Meeting & Exposition, Philadelphia, PA, United States, August 19-23, 2012 (2012), INOR-599.

 

 

45. Gold-Containing and Gold-Generated 1,n-Dipoles as Useful Platforms toward Cycloadditions and Cyclizations

D. Garayalde, C. Nevado*

ACS Catal. (2012), 2, 1462-1479

 

 

 

44. [1,3-Bis-(2,6-diisopropylphenyl)-imidazol-2-ylidene]-chloridogold(I)

A. Linden, T. de Haro, C. Nevado*

Acta Crystallogr., Sect. C: Cryst. Struct. Commun. (2012), C68, m1-m3

 

[Scheme 1]

 

 

43. Gold-Catalyzed 1,2-/1,2-Bisacetoxy Migration of 1,4-Bispropargyl Acetates: A Mechanistic Study

T. de Haro, E. Gómez-Bengoa, R. Cribiú, X. Huang, C. Nevado*

Chem. Eur. J. (2012), 18, 6811-6824

 

 

 

42. Unexpected Outcomes of the Oxidation of (Pentafluorophenyl)triphenylphosphanegold(I)

M. Hofer, C. Nevado*

Eur. J. Inorg. Chem. (2012), 9, 1338-1341

 

 

 

41. On Gold-Mediated C-H Activation Processes

T. de Haro, C. Nevado*

Synthesis (2011), 16, 2530-2539

 

/media/synthesis/201116/m533_ga.jpg

 

 

40. Synthetic Applications on Gold-Catalyzed Ring Expansions

D. Garayalde, C. Nevado*

Beilstein J. Org. Chem. (2011), 7, 767-780

 

1860-5397-7-87

 

 

39. Flexible Gold-Catalyzed Regioselective Oxidative Difunctionalization of Alkenes

T. de Haro, C. Nevado*

Angew. Chem. Int. Ed. (2011), 123, 906-910

 

 

 

38. Gold-Catalyzed Cyclopenta/heptannulation Cascades: A Formal Total Synthesis of (-)-Frondosin A and B

D. Garayalde, K. Kruger, C. Nevado*

Angew. Chem. Int. Ed. (2011), 123, 941-945

 

 

 

37. Gold-Catalyzed Synthesis of α-Fluoroacetals and α-Fluoroketones from Alkynes

T. de Haro, C. Nevado*

Adv. Synth.Cat. (2010), 352, 2767-2772

 

 

 

36. Conference Report: The 45th EUCHEM Conference on Stereochemistry (Burgenstock Conference 2010)

C. Mazet, C. Nevado*

Chimia (2010), 64, 421-424

 

 

35. Synthesis and Evaluation of an Iejimalide-Archazolid Chimera

E. Moulin, C. Nevado, J. Gagnepain, G. Kelter, H. Fiebig, A. Fürstner

Tetrahedron (2010), 66, 6421-6428

 

 

34. Domino Gold-Catalyzed Rearrangement and Fluorination of Propargylacetates

T. de Haro, C. Nevado*

Chem. Commun. (Special Issue Young Investigators) (2011), 47, 248-249

 

Graphical abstract: Domino gold-catalyzed rearrangement and fluorination of propargyl acetates

 

 

33. Gold Catalysis: Recent Developments and Future Trends

C. Nevado*

Chimia (2010), 64, 247-251

 

 

32. Mechanistic Insights in Gold-Stabilized Nonclassical Carbocations: Gold-Catalyzed Rearrangement of 3-Cyclopropyl Propargylic Acetates

D. Garayalde, E. Gòmez-Bengoa, Q. Wang, C. Nevado*, A. Goerke*

J. Am. Chem. Soc. (2010), 132, 4720-4730

 

 

 

31. Gold-Catalyzed Ethynylation of Arenes

T. de Haro, C. Nevado*

J. Am. Chem. Soc. (2010), 132, 1512-151

 

 

 

30. Kinase Selectivity Potential for Inhibitors Targeting the ATP Binding Site: A network Analysis

D. Huang, T. Zhou, K. Lafleur, C. Nevado*, A. Caflisch*

Bioinformatics (2010), 26, 198-204

 

 

29. Syntheses and Biological Evaluation of Iriomoteolide-3a and analogues

R. Cribiú, C. Jäger, C. Nevado*

Angew. Chem. Int. Ed. (2009), 48, 8780-8783

 

 

 

28. Structure-Based Optimization of Potent and Selective Inhibitors of the Tyrosine Kinase EphB4

K. Lafleur, D. Huang, T. Zhou, A. Caflisch*, C. Nevado*

J. Med. Chem. (2009), 52, 6433-6446

 

 

 

27. Gold-Catalyzed Stereocontrolled Synthesis of 2,3-Bisacetoxy-1,3-dienes

X. Huang, T. Haro, C. Nevado*  

Chem. Eur. J. (2009), 15, 5904-5908 (Highlighted in Chimia)

 

 

 

26. Gold-CatalyzedCycloisomerization of CyclopropylAlkynyl Acetates: A Versatile Approach to 5-, 6-, and 7-Membered Carbocycles

Y. Zou, D. Garayalde, Q. Wang, C. Nevado*, A. Goeke*

Angew. Chem. Int. Ed. (2008), 47, 10110-10113

 

 

 

25. The metathesis reaction as a fundamental tool for the synthesis of complex natural products

C. Nevado*

Anales RSEQ (2008), 104, 15 (Invited Contribution)

 

 

Post-doctoral Studies

 

24. Molecular Editing and Assessment of the Cytotoxic Properties of Iejimalide and Progeny

J. Gagnepain, E. Moulin, C. Nevado, M. Waser, A. Maier, G. Kelter, H.-H. Fiebig, A. Fürstner

Chemistry - A European Journal (2011), 17(25), 6973-6984

 

23. Synthesis and evaluation of an Iejimalide-archazolid chimera

E. Moulin, C. Nevado, J. Gagnepain, G. Kelter, H.-H. Fiebig, A. Fürstner

Tetrahedron (2010), 66(33), 6421-6428

 

22. A versatile protocol for Stille-Migita cross coupling reactions

A. Fürstner, J.-A. Funel, M.Tremblay, L. C. Bouchez, C. Nevado, M. Waser, J. Ackerstaff, C. Stimson

Chem. Comm. (2008), 25, 2873-2875

 

21. Total Synthesis of Iejimalide A-D and Assessment of the Remarkable Actin-Depolymerizing Capacity of these Polyene Macrolides

A. Fürstner, C. Nevado, M. Waser, M. Tremblay, C. Chevrier, F. Teply, C. Aïssa, E. Moulin, O. Müller

J. Am. Chem. Soc. (2007), 129, 9150-9161

 

20. Latrunculin Analogues with Improved Biological Profiles by Diverted Total Synthesis: Preparation, Evaluation and Computational Analysis

A. Fürstner, D. Kirk, M. D. B. Fenster, C. Aïssa, D. De Souza, C. Nevado, T. Tuttle, W. Thiel, O. Müller

Chem. Eur. J. (2007), 13, 135-149

 

19. Total synthesis of Iejimalide B

A. Fürstner, C. Nevado, M. Tremblay, C. Chevrier, F. Teply, C. Aïssa, M. Waser

Angew. Chem. Int. Ed. (2006), 45, 5837-5842

 

18. Studies on Iejimalide B. Preparation of the Seco-Acid and Identification of the Molecule´s "Achilles Heel"

A. Fürstner, C. Aïssa, C. Chevrier, F. Teply, C. Nevado, M. Tremblay

Angew. Chem. Int. Ed. (2006), 45,5832-5837

 

17. Towards the total synthesis of Iejimalide B

C. Nevado, C. Aissa, F. Teply, C. Chevrier, M. Tremblay, M. Waser, A. Fürstner

Abstracts of Papers, 232nd ACS National Meeting, San Francisco, CA, United States, Sept. 10-14, 2006 (2006), ORGN-651

 

 

PhD Studies

 

16. Intramolecular Reactions of Alkynes with Alkenes Catalyzed by Platinum and Gold

A. M. Echavarren, C. Nevado, C. Nieto-Oberhuber, M. P. Muñoz, S. López

'New Methodologies and Techniques for a Sustainable Organic Chemistry', Eds. Mordini, F.; Faigl, F.; 2008 , 246, 99-117, Nato Science Series, Series II: Mathematics, Physics and Chemistry

 

15. Missing Cyclization Pathways and New Rearrangements Unveiled in the Gold(I) and Platinum(II)-Catalyzed Cyclization of 1,6-Enynes

C. Ferrer, M. Raducan, C. Nevado, C. Claverie, A. M. Echavarren

Tetrahedron (2007), 63, 6306-6316

 

14. Gold(I)-Catalyzed Cyclizations of 1,6-Enynes: Alcoxycyclizations and Exo/Endo Skeletal Rearrangements

C. Nieto-Oberhuber, M. P. Muñoz, S. López, E. Jiménez, C. Nevado, E. Herrero-Gómez, M. Raducan, A. M. Echavarren

Chem. Eur. J. (2006), 12, 1677-1693

 

13. Divergent Mechanisms for the Skeletal Rearrangement and [2 + 2] Cycloaddition of Enynes Catalyzed by Gold

C. Nieto-Oberhuber, S. López, M. P. Muñoz, D. J. Cárdenas, E. Buñuel, C. Nevado, A. M. Echavarren

Angew. Chem. Int. Ed. (2005), 44, 6146-6148

 

12. Intramolecular Hydroarylation of Alkynes Catalyzed by Platinum or Gold: Mechanism and Endo Selectivity

C. Nevado, A. M. Echavarren

Chem. Eur. J. (2005), 11, 3155-3164

 

11. Transition Metal Catalyzed Arylation of Alkynes

C. Nevado, A. M. Echavarren

Synthesis (2005), 2, 167-182

 

10. New Annulations Via Platinum-Catalyzed Enyne Cyclization and Cyclopropane Cleavage

C. Nevado, C. Ferrer, A. M. Echavarren

Org. Lett. (2004), 6, 3191-3194

 

9. Palladium(II)-Catalyzed Isomerization-Claisen Rearrangement of 2-Alkoxy Diallyl Ethers

C. Nevado, a. M. Echavarren

Tetrahedron (Symposium in Print) (2004), 60, 9735-9744

 

8. Non-Stabilized Transition Metal Carbenes as Intermediates in Intramolecular Reactions of Alkynes with Alkenes

A. M. Echavarren, C. Nevado

Chem. Soc. Rev. (2004), 33, 431-436

 

7. Cationic Gold(I) Complexes: Highly Alkynophilic Catalysts for the Exo- and Endo-Cyclization of Enynes

C. Nieto-Oberhuber, M. P. Muñoz, E. Buñuel, C. Nevado, D. J. Cárdenas, A. M. Echavarren

Angew. Chem. Int. Ed. (2004), 43, 2402-2408

 

6. Metal CyclopropylCarbenes in the Reactions of Alkynes with Alkenes and Furans

A. M. Echavarren, M. Méndez, M. P. Muñoz, C. Nevado, B. Martín-Matute, C. Nieto-Oberhuber, D. J. Cárdenas

Pure Appl. Chem. (2004), 76, 453-463

 

5. Hydroxy- and Alkoxycyclizations of Enynes Catalyzed by PtCl2

M. P. Muñoz, M. Méndez, C. Nevado, D. J. Cárdenas, A. M. Echavarren

Synthesis (2003), 18, 2898-2902

 

4. Intramolecular Reactions of Alkynes with Furans and Electron Rich Arenes Catalyzed by PtCl2: The Role of Platinum Carbenes as Intermediates

B. Martín-Matute, C. Nevado, D. J. Cárdenas, A. M. Echavarren

J. Am. Chem. Soc. (2003), 125, 5757-5766

 

3. Reaction of Enol Ethers with Alkynes Catalyzed by Transition Metals: 5-Exo-Dig vs. 6-Endo-Dig Cyclizations via Cyclopropyl Platinum or Gold Carbene Complexes

C. Nevado, D. J. Cárdenas, A. M. Echavarren

Chem. Eur. J. (2003), 9, 2627-2635

 

2. On the Mechanism of Carbohydroxypalladation of Enynes. Additional Insights on the Cyclization of Enynes with Electrophilic Metal Complexes

C. Nevado, L. Charruault, V. Michelet, C. Nieto-Oberhuber, M. P. Muñoz, M. Méndez, M. N. Rager, J. P. Genêt, A. M. Echavarren

Eur. J. Org. Chem. (2003), 706-713

 

1. Cyclizations of Enynes Catalyzed by PtCl2 or Other Transition Metal Chlorides: Divergent Reaction Pathways

M. Méndez, M. P. Muñoz, C. Nevado, D. J. Cárdenas, A. M. Echavarren

J. Am. Chem. Soc. (2001), 123, 10511-10520

 

 

Patents

 

4. Anti-angiogenic Compounds

D. Huang, P. Kolb, K. Lafleur, C. Nevado, A. Caflisch

PCT Int. Appl. (2014), WO 2009092602 US 2010-863724

 

3. Preparation of Imidazopurinedione Derivatives as Antiangiogenic EphB4 Kinase Inhibitors Useful in the Treatment of Angiogenesis Dependent Cancers and Intraocular Neovascular Syndromes

K. Lafleur, D. Huang,C. Nevado, A. Caflisch

PCT Int. Appl. (2011), WO 2011009695 A1 20110127

 

2. Preparation of Imidazopurinones as EphB4 Inhibitors Useful for the Treatment of Angiogenesis Dependent Cancers and Intraocular Neovascular Syndromes

D. Huang, P. Kolb, C. Nevado*, A. Caflisch*

PCT Int. Appl. (2009), WO 2009092602 A2 20090730

 

1. Preparation of Iejimalide Analogs and Uses Thereof as Chemotherapeutic Agents

A. Fürstner, C. Nevado, M. Waser, E. Moulin, C. Aïssa

PCT Int. Appl. (2008), WO 2008113320 A1 20080925